Phosphorylation of Rhoptry Protein RhopH3 Is Critical for Host Cell Invasion by the Malaria Parasite
Roseleen Ekka, Ankit Gupta, Sonika Bhatnagar, Pawan Malhotra, Pushkar Sharma
Abstract
Host cell invasion by the malaria parasite is critical for establishing infection in human host and is dependent on discharge of key ligands from organelles like rhoptry and microneme, and these ligands interact with host RBC receptors. In the present study, we demonstrate that phosphorylation of a key rhoptry protein, RhopH3, is critical for host invasion. Phosphorylation regulates its localization to rhoptries and discharge from the parasite.
Topics & Concepts
RhoptryMicronemePhosphorylationParasite hostingCell biologyOrganelleMalariaHost (biology)BiologyPlasmodium falciparumImmunologyApicomplexaGeneticsComputer scienceWorld Wide WebMalaria Research and ControlInvertebrate Immune Response MechanismsMosquito-borne diseases and control