Design, synthesis and pharmacological evaluation of 2,3-dihydrobenzofuran IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma
Yun Chen, Yi Ning, Zhiwei Chen, Yaping Xue, Qing‐Yun Wu, Wenhu Duan, Jian Ding, Jinpei Zhou, Hua Xie, Huibin Zhang
Topics & Concepts
IbrutinibChemistryBruton's tyrosine kinaseTyrosine kinaseLymphomaCancer researchDiffuse large B-cell lymphomaKinaseApoptosisPharmacologySignal transductionChronic lymphocytic leukemiaBiochemistryImmunologyBiologyLeukemiaProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysToxin Mechanisms and Immunotoxins