Segregation of D1 and D2 dopamine receptors in the striatal direct and indirect pathways: An historical perspective
Charles R. Gerfen
Abstract
The direct and indirect striatal pathways form a cornerstone of the circuits of the basal ganglia. Dopamine has opponent affects on the function of these pathways due to the segregation of the D1- and D2-dopamine receptors in the spiny projection neurons giving rise to the direct and indirect pathways. An historical perspective is provided on the discovery of dopamine receptor segregation leading to models of how the direct and indirect affect motor behavior.
Topics & Concepts
Direct pathway of movementIndirect pathway of movementNeuroscienceDopamineBasal gangliaMedium spiny neuronDopamine receptor D2Dopamine receptorDopamine receptor D1Perspective (graphical)PsychologyBiologyStriatumComputer scienceCentral nervous systemArtificial intelligenceNeurotransmitter Receptor Influence on BehaviorNeurological disorders and treatmentsNeuroscience and Neuropharmacology Research