Efficient and Recoverable Bio-Organic Catalyst Cysteine for Synthesis, Docking Study, and Antifungal Activity of New Bio-Active 3,4-Dihydropyrimidin-2(1<i>H</i>)-ones/thiones Under Microwave Irradiation
Nadia A. A. Elkanzi, Asmaa M. Kadry, Rasha M. Ryad, Rania B. Bakr, Mahmoud Abd El Aleem Ali Ali El‐Remaily, Ali M. Ali
Abstract
. Excellent yields (90-98%) were obtained within short reaction times, and problems associated with the toxic solvents used (cost, safety, and pollution) were avoided. The structures of the new compounds were elucidated by elemental and spectral analyses. All compounds were studied using molecular docking, and their antifungal activity was investigated.
Topics & Concepts
AcetylacetoneEthyl acetoacetateChemistryCatalysisThioureaOrganic chemistryGreen chemistryOrganometallic chemistryMalononitrileNuclear chemistryReaction mechanismSynthesis and biological activityMulticomponent Synthesis of HeterocyclesSynthesis and Characterization of Heterocyclic Compounds