The Pyridotriazole Works as a Traceless Directing Group: A C–H Activation/Annulation Cascade Reaction with Iodonium Ylides
Guanghui Lv, Qingyao Zhang, Cuimei Zhang, Yuting Chen, Lin Zheng, Ruizhi Lai, Zhongzhen Yang, Yong Wu
Abstract
A novel Rh-catalyzed cascade reaction of pyridotriazoles with iodonium ylides is reported. This one-pot procedure involves a triazole-directed ortho -position C–H carbene insertion, followed by intramolecular denitrogenation annulation. It was noteworthy that this reaction provided straightforward access to 1 H -isochromene frameworks with excellent yields (up to 94% yield).
Topics & Concepts
AnnulationChemistryIntramolecular forceYield (engineering)CascadeCarbeneCascade reactionCatalysisMedicinal chemistryCombinatorial chemistryReaction conditionsStereochemistryOrganic chemistryMetallurgyChromatographyMaterials scienceCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions