Discovery of novel thiophene derivatives as potent neuraminidase inhibitors
Zhi Jian Zhong, Xiao Hu, Li Ping Cheng, Xing Yong Zhang, Qiang Zhang, Zhang Ju
Topics & Concepts
ChemistryPharmacophoreThiopheneLead compoundNeuraminidaseDocking (animal)StereochemistryMoietyVirtual screeningQuinolineIC50Combinatorial chemistryZanamivirStructure–activity relationshipActive siteRing (chemistry)In silicoEnzymeIn vitroBiochemistryOrganic chemistryNursingDiseaseCoronavirus disease 2019 (COVID-19)GeneInfectious disease (medical specialty)PathologyMedicineInfluenza Virus Research StudiesSynthesis and Biological EvaluationAntimicrobial Peptides and Activities