Microfabricated Solid‐contact Potentiometric Sensor for Determination of Tedizolid Phosphate, Application to Content Uniformity Testing
Amr M. Mahmoud, Eman M. Moaaz, Mamdouh R. Rezk, Ezzat M. Abdel‐Moety, Ahmed S. Fayed
Abstract
Abstract Solid contact sensors were designed for determination of the antibiotic prodrug tedizolid phosphate. The sensors are based on; microfabricated copper as cost‐effective electrode substrate and graphene layer as a transducer. The ion sensing PVC polymeric membrane was optimized by proper selection of the anion exchanger. The graphene layer was characterized by scanning electron microscopy, Raman spectroscopy, FT‐IR, besides measuring electrochemical impedance for the fabricated sensors. The potential drift decreased down to 0.133 mV h −1 compared to 6.67 mV h −1 for graphene free sensor. The sensors have been used to determine tedizolid phosphate in its pharmaceutical formulation and content uniformity testing applications.