Hypoxia inducible factor (HIF) 3α prevents COPD by inhibiting alveolar epithelial cell ferroptosis via the HIF-3α-GPx4 axis
Junchao Jiang, Zhoude Zheng, Shengsong Chen, Jixiang Liu, Ju Jia, Yuhang Huang, Qing Liu, Chung Yan Cheung, Don D. Sin, Ting Yang, Chen Wang
Abstract
Hypoxia and oxidation-related damage begins years before the onset of COPD symptoms, suggesting the imbalance and impairment of intracellular homeostatic system. The activation of the HIF-3α-GPx4 axis is a promising treatment target. By leveraging this comprehensive analysis method, more potential targets could be found and enhancing our understanding of the pathogenesis.
Topics & Concepts
Hypoxia (environmental)Hypoxia-inducible factorsCOPDCell biologyCellHIF1AHypoxia-Inducible Factor 1ChemistryCancer researchTranscription factorMedicineBiologyOxygenInternal medicineAngiogenesisBiochemistryGeneOrganic chemistryCancer-related molecular mechanisms researchRNA modifications and cancerPulmonary Hypertension Research and Treatments