Circular RNA circDLC1 inhibits MMP1-mediated liver cancer progression via interaction with HuR
Hailing Liu, Tian Lan, Hui Li, Lin Xu, Xing Chen, Haotian Liao, Xi Chen, Jinpeng Du, Yunshi Cai, Jinju Wang, Xuefeng Li, Jiwei Huang, Kefei Yuan, Yong Zeng
Abstract
Our work suggests that circDLC1, a downstream target of KIAA1429, is a promising prognostic marker for HCC patients, and the circDLC1-HuR-MMP1 axis may serve as a potential therapeutic target for HCC treatment.
Topics & Concepts
Circular RNAMethyltransferaseHepatocellular carcinomaCancer researchMethylationTumor progressionCancerRNALiver cancerMMP1microRNAMatrix metalloproteinaseBiologyRNA methylationDNA methylationGeneGene expressionGeneticsCircular RNAs in diseasesRNA modifications and cancerMicroRNA in disease regulation