Investigating the role of platelets and platelet-derived transforming growth factor-β in idiopathic pulmonary fibrosis
Deborah L. W. Chong, Theresia Mikolasch, Jagdeep Sahota, Carine Rebeyrol, Helen Garthwaite, Helen Booth, Melissa Heightman, Emma Denneny, Ricardo J. José, Akif A. Khawaja, Anna Duckworth, Myriam Labelle, Chris J. Scotton, Joanna C. Porter
2023American Journal of Physiology-Lung Cellular and Molecular Physiology15 citationsDOIOpen Access PDF
Abstract
Platelets are a rich source of profibrotic TGFβ; however, the role of platelets in idiopathic pulmonary fibrosis (IPF) is unclear. We identified that patients with IPF have significantly more platelets, neutrophils, and active TGFβ in their airways than control patients. Using an animal model of IPF, we demonstrated that platelet-derived TGFβ does not significantly drive lung fibrosis or inflammation. Our findings offer a better understanding of platelets in both human and animal studies of IPF.
Topics & Concepts
PlateletIdiopathic pulmonary fibrosisMedicinePulmonary fibrosisTransforming growth factorInflammationFibrosisLungImmunologyPathologyInternal medicineInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisPleural and Pulmonary DiseasesChronic Obstructive Pulmonary Disease (COPD) Research