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A functional hiPSC-cortical neuron differentiation and maturation model and its application to neurological disorders

Kaveena Autar, Xiufang Guo, John W. Rumsey, Christopher J. Long, Nesar Akanda, Max Jackson, Narasimhan S. Narasimhan, Julbert Caneus, Dave Morgan, James J. Hickman

2021Stem Cell Reports71 citationsDOIOpen Access PDF

Abstract

receptor antagonist picrotoxin in day 21 cultures. This system was also applied to epilepsy modeling utilizing bicuculline and its correction utilizing the anti-epileptic drug valproic acid.

Topics & Concepts

BiologyNeuroscienceNeuronNeuroscience and Neuropharmacology ResearchNeurological disorders and treatmentsNeuroscience and Neural Engineering
A functional hiPSC-cortical neuron differentiation and maturation model and its application to neurological disorders | Litcius