Borrelia burgdorferi DnaA and the Nucleoid-Associated Protein EbfC Coordinate Expression of the <i>dnaX-ebfC</i> Operon
Andrew C. Krusenstjerna, Timothy C. Saylor, William K. Arnold, Jamila S. Tucker, Brian Stevenson
Abstract
The dual life cycle of Borrelia burgdorferi , the causative agent of Lyme disease, is characterized by periods of rapid and slowed replication. The expression patterns of many of the spirochete’s virulence factors are impacted by these changes in replication rates.
Topics & Concepts
DnaABiologyBorrelia burgdorferiOperonGeneticsDNA replicationVirologyOrigin of replicationGeneEscherichia coliAntibodyVector-borne infectious diseasesToxin Mechanisms and ImmunotoxinsInsect symbiosis and bacterial influences