Versatile iron-vitamin K3 derivative-based nanoscale coordination polymer augments tumor ferroptotic therapy
Zhicheng Zhang, Yawen Ding, Jinbiao Li, Li Wang, Xiaoyan Xin, Jing Yan, Jinhui Wu, Ahu Yuan, Yiqiao Hu
Abstract
Ferroptosis is a newly form of regulated cell death, which has attracted great attention for tumor therapy. Herein, we prepared nanoscale coordination polymer Fe-NQA particles to deliver iron and NQA (vitamin K3 derivative) into tumor cells, which synergistically promoted ferroptotic therapy for inhibiting tumor growth, preventing metastasis, and overcoming radioresistance.
Topics & Concepts
RadioresistanceCancer researchNanoscopic scaleDerivative (finance)MetastasisChemistryNanotechnologyRadiation therapyMaterials scienceMedicineCancerInternal medicineBusinessFinancePeptidase Inhibition and AnalysisMXene and MAX Phase MaterialsFerroptosis and cancer prognosis