CDK12 inhibition enhances sensitivity of HER2+ breast cancers to HER2-tyrosine kinase inhibitor via suppressing PI3K/AKT
Hui Li, Jinsong Wang, Zongbi Yi, Chunxiao Li, Haijuan Wang, Jingyao Zhang, Ting Wang, Peng Nan, Feng Lin, Dongkui Xu, Haili Qian, Fei Ma
Topics & Concepts
Protein kinase BCancer researchTyrosine kinasePI3K/AKT/mTOR pathwayTyrosine-kinase inhibitorReceptor tyrosine kinaseMedicineChemistryInternal medicinePhosphorylationReceptorSignal transductionCancerBiochemistryAdvanced Breast Cancer TherapiesHER2/EGFR in Cancer ResearchCancer-related Molecular Pathways