Structure-Based Rational Design of Small α-Helical Peptides with Broad-Spectrum Activity against Multidrug-Resistant Pathogens
Sandeep Lohan, Anastasia G. Konshina, Roman G. Efremov, Innokentiy Maslennikov, Keykavous Parang
Abstract
and its closest analogues with bacterial and mammalian membranes and revealed the roles of particular amino acids in the activity and selectivity of peptides.
Topics & Concepts
ChemistryCircular dichroismPeptideCalceinLipid bilayerAmphiphileRational designSelectivityStereochemistryMembraneBiochemistryBiophysicsCombinatorial chemistryOrganic chemistryNanotechnologyBiologyCopolymerMaterials sciencePolymerCatalysisAntimicrobial Peptides and ActivitiesImmune Response and InflammationRNA Interference and Gene Delivery