Silicon–nitrogen bond formation <i>via</i> dealkynative coupling of amines with bis(trimethylsilyl)acetylene mediated by KHMDS
Krzysztof Kuciński, Grzegorz Hreczycho
Abstract
The catalytic synthesis of silylamines mediated by s- and p-block catalysts is largely underdeveloped. Herein, commercially available potassium bis(trimethylsilyl)amide serves as an efficient alternative to transition metal complexes. N-H/Si-C dealkynative coupling was achieved by means of user-friendly main-group catalysis with ample substrate scope and high chemoselectivity.
Topics & Concepts
ChemoselectivityTrimethylsilylAcetyleneCatalysisSubstrate (aquarium)AmideChemistryCombinatorial chemistryTransition metalNitrogenSiliconPolymer chemistryOrganic chemistryOceanographyGeologyOrganoboron and organosilicon chemistryCatalytic Cross-Coupling ReactionsChemical Synthesis and Analysis