Exercise-Induced MYC as an Epigenetic Reprogramming Factor That Combats Skeletal Muscle Aging
Ronald G. Jones, Ferdinand von Walden, Kevin A. Murach
Abstract
Of the "Yamanaka factors" Oct3/4 , Sox2 , Klf4 , and c-Myc (OSKM), the transcription factor c-Myc ( Myc ) is the most responsive to exercise in skeletal muscle and is enriched within the muscle fiber. We hypothesize that the pulsatile induction of MYC protein after bouts of exercise can serve to epigenetically reprogram skeletal muscle toward a more resilient and functional state.
Topics & Concepts
KLF4Skeletal muscleReprogrammingTranscription factorEpigeneticsBiologySOX2Cell biologyEndocrinologyGeneticsGeneAdipose Tissue and MetabolismEpigenetics and DNA MethylationMuscle Physiology and Disorders