Dual-Functional Plasmonic Photothermal Biosensors for Highly Accurate Severe Acute Respiratory Syndrome Coronavirus 2 Detection
Guangyu Qiu, Zhibo Gai, Yile Tao, Jean Schmitt, Gerd A. Kullak‐Ublick, Jing Wang
Abstract
hybridization temperature and facilitate the accurate discrimination of two similar gene sequences. Our dual-functional LSPR biosensor exhibits a high sensitivity toward the selected SARS-CoV-2 sequences with a lower detection limit down to the concentration of 0.22 pM and allows precise detection of the specific target in a multigene mixture. This study gains insight into the thermoplasmonic enhancement and its applicability in the nucleic acid tests and viral disease diagnosis.
Topics & Concepts
Photothermal therapyBiosensorSurface plasmon resonancePlasmonCoronavirusNanotechnologyNucleic acidVirologyMaterials scienceBiologyComputational biologyCoronavirus disease 2019 (COVID-19)MedicineInfectious disease (medical specialty)OptoelectronicsDiseaseNanoparticleGeneticsPathologySARS-CoV-2 and COVID-19 ResearchSARS-CoV-2 detection and testingBiosensors and Analytical Detection