2-Azidoacrylamides as compact platforms for efficient modular synthesis
Hinano Takemura, Sayuri Goto, Takamitsu Hosoya, Suguru Yoshida
Abstract
Efficient methods to assemble modules with compact platform molecules by triazole formations and Michael reactions are disclosed. The good electrophilicity of 2-triazolylacrylamides realized Michael additions using various nucleophiles. An iterative synthesis of a tetrakis(triazole) was accomplished by orthogonal triazole formations and Michael reactions.
Topics & Concepts
NucleophileElectrophileModular designMichael reactionCombinatorial chemistryComputer scienceMoleculeChemistryNanotechnologyMaterials scienceProgramming languageOrganic chemistryCatalysisClick Chemistry and ApplicationsChemical Synthesis and AnalysisMonoclonal and Polyclonal Antibodies Research