The dual-effects of PLGA@MT electrospun nanofiber coatings on promoting osteogenesis at the titanium–bone interface under diabetic conditions
Zijie Wang, Tingting Chen, Zimei Wu, Xingzhu Jiang, Qiaodan Hou, Sikai Miao, Ruihao Xia, Lin Wang
Abstract
experiments revealed that PLGA@MT-Ti screws promoted the bone formation and osteointegration in type 1 diabetes mellitus (T1DM) mice with tibial bone defects. Our findings demonstrate that PLGA@MT-Ti exerted dual effects through activating the BMP-4/WNT pathway and attenuating ROS overproduction to promote osteogenesis and osteointegration at the Ti-B interface, providing a novel strategy to fabricate biomaterial modification and biofunctionalization under diabetic conditions.
Topics & Concepts
Materials scienceNanofiberPLGATitaniumElectrospinningDual (grammatical number)Interface (matter)Biomedical engineeringNanotechnologyComposite materialMetallurgyMedicineNanoparticlePolymerContact angleArtSessile drop techniqueLiteratureBone Tissue Engineering MaterialsElectrospun Nanofibers in Biomedical ApplicationsGraphene and Nanomaterials Applications