Single-nucleotide variants within heart enhancers increase binding affinity and disrupt heart development
Granton A. Jindal, Alexis Bantle, Joe J. Solvason, Jessica L. Grudzien, Agnieszka D’Antonio‐Chronowska, Fabian Lim, Sophia H. Le, Benjamin P. Song, Michelle Franc Ragsac, Adam Klie, Reid O. Larsen, Kelly A. Frazer, Emma K. Farley
Topics & Concepts
BiologyEnhancerPhenotypeGeneInduced pluripotent stem cellGeneticsGene expressionRegulation of gene expressionComputational biologyTranscription factorEmbryonic stem cellCongenital heart defects researchRNA and protein synthesis mechanismsRNA modifications and cancer