A biodegradable nanodrug with highly efficient treatment effect by remodeling tumor microenvironment and manipulating energy metabolism against colorectal cancer
Shaopeng Zhang, Hao Zhang, Peizhe Song, Yue Cao, Wei Li, Daguang Wang, Yinghui Wang, Hongjie Zhang
Topics & Concepts
Colorectal cancerChemotherapyCancer researchTumor microenvironmentIn vivoChemistryHypoxia (environmental)PharmacologyGlutathioneReactive oxygen speciesHexokinaseGlycolysisCancerMetabolismMedicineBiochemistryInternal medicineBiologyEnzymeOxygenOrganic chemistryBiotechnologyTumor cellsNanoplatforms for cancer theranosticsCancer, Hypoxia, and MetabolismNanoparticle-Based Drug Delivery