Unsaturated phospholipid modified FeOCl nanosheets for enhancing tumor ferroptosis
Zi He, Yijun Guo, Jinzhu Chen, Huiling Luo, Xinxin Liu, Xiuming Zhang, Yanan Sun, Dongtao Ge, Shefang Ye, Wei Shi
Abstract
results confirmed that FeOCl@PAA-Lip nanosheets exhibited specific tumor cell-killing effects, good biocompatibility, long circulation time, low side effects, high tumor targeting and an excellent tumor inhibition rate (73%). The Lip functionalization strategy offers a paradigm of enhancing ferroptosis treatment by conversion of ˙OH/phospholipid radicals/lipid peroxyl radicals and strengthening lipid peroxidation.
Topics & Concepts
Polyacrylic acidPhospholipidMaterials scienceChemistryChemical engineeringBiophysicsBiochemistryMembranePolymerComposite materialBiologyEngineeringNanoplatforms for cancer theranosticsExtracellular vesicles in diseaseAdvanced Nanomaterials in Catalysis