p53 plays a central role in the development of osteoporosis
Tao Yu, Xiaomeng You, Haichao Zhou, Alex Kang, Wenbao He, Zihua Li, Bing Li, Jiang Xia, Hui Zhu, Youguang Zhao, Guangrong Yu, Yuan Xiong, Yunfeng Yang
Abstract
gene expression and serum p53 levels were upregulated in osteoporotic patients and a mouse osteoporosis model. The elevated p53 levels were associated with decreases in bone mass, which could be partially reversed by knocking down p53. These findings suggest p53 may play a central role in the development of osteoporosis.
Topics & Concepts
OsteoporosisGeneMicroarray analysis techniquesMicroarrayDownregulation and upregulationCyclin-dependent kinase 1BioinformaticsDiseaseMedicineBiologyInternal medicineGene expressionCancer researchOncologyCell cycleGeneticsBone Metabolism and DiseasesBone health and osteoporosis researchBone health and treatments