ALDH3A1 acts as a prognostic biomarker and inhibits the epithelial mesenchymal transition of oral squamous cell carcinoma through IL-6/STAT3 signaling pathway
Yi Qu, Ying He, Yang� Yang, Yan Li, Wei An, Zhilin Li, Xue Wang, Zhengxue Han, Lizheng Qin
Abstract
Objectives: Aldehyde dehydrogenase 3A1 (ALDH3A1) is a member of the ALDH superfamily and its relationship with oral squamous cell carcinoma (OSCC) still unknown. In our subject, we aimed to reveal the expression pattern and clinical value of ALDH3A1 in OSCC and its biological function in OSCC cell lines.
Topics & Concepts
Epithelial–mesenchymal transitionCancer researchVimentinApoptosisPathologyImmunohistochemistryBiologyCellSTAT3Signal transductionMetastasisCancerMedicineInternal medicineCell biologyBiochemistryGeneticsCancer Cells and MetastasisCancer-related molecular mechanisms researchCancer, Hypoxia, and Metabolism