Sapidolide A alleviates acetaminophen-induced acute liver injury by inhibiting NLRP3 inflammasome activation in macrophages
Jin-cheng Wang, Jin-cheng Wang, Qi Shi, Qian Zhou, Lu-lu Zhang, Yue-ping Qiu, Da-yong Lou, Li-qin Zhou, Bo Yang, Qiao-jun He, Qin-jie Weng, Jia-jia Wang, Jia-jia Wang
Topics & Concepts
PyroptosisInflammasomeLiver injuryAcetaminophenPharmacologyIn vivoHepatocytePathogenesisMedicineProinflammatory cytokineInflammationChemistryCaspase 1Cell cultureProgrammed cell deathIn vitroImmunologyCancer researchCD14Liver cellTHP1 cell lineNecrosisSignal transductionTumor necrosis factor alphaCellDrug-Induced Hepatotoxicity and ProtectionInflammasome and immune disordersThermal Regulation in Medicine