Copper-Catalyzed Decarboxylative Cycloaddition of Propiolic Acids, Azides, and Arylboronic Acids: Construction of Fully Substituted 1,2,3-Triazoles
Xiangxiang Wang, Yangchun Xin, Yi Li, Yi Li, Wen‐Jin Xia, Bin Zhou, Rui‐Rong Ye, Ya-Min Li, Ya-Min Li
Abstract
A copper-catalyzed decarboxylative cycloaddition of propiolic acids, azides, and arylboronic acids is described. The present reaction provides an efficient and convenient method for the synthesis of various fully substituted 1,2,3-triazoles from readily available starting materials. A possible mechanism is proposed.
Topics & Concepts
ChemistryCycloadditionCatalysisCopperCombinatorial chemistryOrganic chemistryClick Chemistry and ApplicationsCyclopropane Reaction MechanismsChemical Synthesis and Analysis