Subdiaphragmatic vagal nerve stimulation attenuates the development of hypertension and alters nucleus of the solitary tract transcriptional networks in the spontaneously hypertensive rat
Elliott W. Dirr, Ladan G. Jiracek, David M. Baekey, Christopher J. Martyniuk, Kevin J. Otto, Jasenka Zubcevic
Abstract
We show that stimulation of the ventral subdiaphragmatic vagal nerve branch may be a promising potential approach to treating hypertension. The data are especially encouraging given that rodents received only 30 min per day of intermittent stimulation therapy and in view of the potential of long-term blood pressure effects that are not stimulus-locked.
Topics & Concepts
Solitary tractBiologyStimulationNucleusVagus nerveSolitary nucleusEndocrinologyNerve stimulationInternal medicineAnatomyNeuroscienceMedicineVagus Nerve Stimulation ResearchHeart Rate Variability and Autonomic ControlNeuroscience of respiration and sleep