A loss-of-function variant in SUV39H2 identified in autism-spectrum disorder causes altered H3K9 trimethylation and dysregulation of protocadherin β-cluster genes in the developing brain
Shabeesh Balan, Yoshimi Iwayama, Tetsuo Ohnishi, Mikiko Fukuda, A Shirai, Ayumi Yamada, Sara Weirich, Maren Kirstin Schuhmacher, K.V. Dileep, Toshihiro Endo, Yasuko Hisano, Kaoru Kotoshiba, Tomoko Toyota, Takeshi Otowa, Hitoshi Kuwabara, Mamoru Tochigi, Akiko Watanabe, Hisako Ohba, Motoko Maekawa, Manabu Toyoshima, Tsukasa Sasaki, Kazuhiko Nakamura, Masatsugu Tsujii, Hideo Matsuzaki, Kam Y. J. Zhang, Albert Jeltsch, Yoichi Shinkai, Takeo Yoshikawa
Topics & Concepts
Histone methylationMethyltransferaseEpigeneticsHistone methyltransferaseBiologyAutismGeneticsHistoneAutism spectrum disorderMethylationDNA methylationGeneGene expressionPsychologyPsychiatryAutism Spectrum Disorder ResearchCancer-related gene regulationGenetics and Neurodevelopmental Disorders