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Computational insights into the molecular mechanisms of differentiated allosteric modulation at the mu opioid receptor by structurally similar bitopic modulators

Huiqun Wang, Bethany A. Reinecke, Yan Zhang

2020Journal of Computer-Aided Molecular Design14 citationsDOI

Topics & Concepts

Allosteric regulationChemistryAllosteric modulatorFunctional selectivityOpioidPharmacologyReceptorStructure–activity relationshipOpioid receptorIntrinsic activityStereochemistryG protein-coupled receptorBiophysicsBiochemistryIn vitroAgonistBiologyReceptor Mechanisms and SignalingNeuropeptides and Animal PhysiologyPharmacological Receptor Mechanisms and Effects
Computational insights into the molecular mechanisms of differentiated allosteric modulation at the mu opioid receptor by structurally similar bitopic modulators | Litcius