A non-viral and selection-free COL7A1 HDR approach with improved safety profile for dystrophic epidermolysis bullosa
Thomas Köcher, Johannes Bischof, Simone Haas, Oliver Patrick March, Bernadette Liemberger, Stefan Hainzl, Julia Illmer, Anna Hoog, Katharina Muigg, Heide‐Marie Binder, Alfred Klausegger, Dirk Strunk, Johann Bauer, Toni Cathomen, Ulrich Koller
Abstract
-editing strategy, associated with a significantly improved safety profile. Our findings, therefore, represent a further advancement in the field of traceless genome editing for genodermatoses.
Topics & Concepts
Epidermolysis bullosaDermatologySelection (genetic algorithm)MedicineComputer scienceArtificial intelligenceSkin and Cellular Biology ResearchAnimal Genetics and ReproductionViral Infectious Diseases and Gene Expression in Insects