Acute Heart Failure 29 Years After Treatment for Childhood Cancer
Massimiliano Camilli, Marco Giuseppe Del Buono, Filippo Crea, Giorgio Minotti
Abstract
Doxorubicin and other antitumor anthracyclines can cause cardiomyopathy and heart failure (HF) in a dose-related manner, with a cumulative dose of 400 mg/m2 of doxorubicin equivalent associated with 5% risk of HF in adults; however, children and the elderly may develop HF after significantly lower
Topics & Concepts
DoxorubicinHeart failureMedicineCumulative doseCardiomyopathyCancerInternal medicineChildhood cancerCardiologyOncologyChemotherapyChemotherapy-induced cardiotoxicity and mitigationChildhood Cancer Survivors' Quality of LifeCancer Treatment and Pharmacology