Real-time imaging of alkaline phosphatase activity of diabetes in mice <i>via</i> a near-infrared fluorescent probe
Wenxin Wang, Wen‐Li Jiang, Hong Guo, Yongfei Li, Chunyan Li
Abstract
A novel water-soluble near-infrared fluorescent probe named QX-P with simple synthesis is developed. QX-P has high sensitivity and selectivity to ALP. Moreover, the probe can not only visualize ALP activity in four cell lines, but also real-time image ALP activity during the diagnosis and treatment of diabetes in mice.
Topics & Concepts
FluorescenceAlkaline phosphataseInfraredChemistryBiochemistryEnzymeOpticsPhysicsSulfur Compounds in BiologyNanoplatforms for cancer theranosticsAlkaline Phosphatase Research Studies