The Sulfated Steroids Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate Inhibit the α1β3γ2L GABAA Receptor by Stabilizing a Novel Nonconducting State
Spencer R. Pierce, Allison L. Germann, Joe Henry Steinbach, Gustav Akk
Topics & Concepts
Pregnenolone sulfateNeuroactive steroidPregnenoloneDehydroepiandrosterone sulfateGABAA receptorSulfationDehydroepiandrosteroneChemistryReceptorPregnanoloneEndocrinologySteroidInternal medicineInhibitory postsynaptic potentialSulfateBiophysicsBiochemistryHormoneBiologyAndrogenMedicineOrganic chemistryNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and SignalingPharmacological Receptor Mechanisms and Effects