GSH-Triggered NO releasing nanoplatform based on a covalent organic framework for “1 + 1 > 2” synergistic cancer therapy
Xiuyan Wan, Teng Zheng, Dawei Wang, Wei Pan, Yanan Gao, Na Li, Bo Tang
Abstract
A porphyrin containing covalent organic framework (COF) was developed as the glutathione responsive nitric oxide (NO) donor delivery nanoplatform for "1 + 1 > 2" synergistic cancer therapy of NO mediated therapy and photodynamic therapy.
Topics & Concepts
Photodynamic therapyGlutathionePorphyrinCovalent bondCancer therapyChemistryNitric oxideCovalent organic frameworkCombinatorial chemistryCancerPharmacologyPhotochemistryBiochemistryOrganic chemistryMedicineInternal medicineEnzymeNanoplatforms for cancer theranosticsMetal-Organic Frameworks: Synthesis and ApplicationsCovalent Organic Framework Applications