Diagnostic Accuracy and Value of CXCR4-targeted PET/MRI Using <sup>68</sup>Ga-Pentixafor for Tumor Localization in Cushing Disease
Yue Wu, Yanfei Wu, Boyuan Yao, Shuhua Ren, Shiman Wu, Wenting Rui, Min He, Yulong Zhang, Yifei Yu, Hongying Ye, Zhaoyun Zhang, Zhen Ye, Rui Han, Nidan Qiao, Yichao Zhang, Xuejie Yu, Zengyi Ma, Yongfei Wang, Yao Zhao, Yihui Guan, Fang Xie, Qilin Zhang, Zhenwei Yao
Abstract
In a prospective study involving 43 participants with Cushing disease, the incorporation of gallium 68 ( 68 Ga) pentixafor PET/MRI demonstrated promising sensitivity, which was higher than contrast-enhanced MRI alone in localizing adrenocorticotropic hormone–secreting pituitary tumors.
Topics & Concepts
MedicineCushing's diseaseProspective cohort studyAdrenocorticotropic hormoneNuclear medicineDiagnostic accuracyCXCR4PathologyRadiologyDiseaseInternal medicineHormoneChemokineReceptorPituitary Gland Disorders and TreatmentsGlioma Diagnosis and TreatmentAdrenal and Paraganglionic Tumors