Phase dependent encapsulation and release profile of ZIF-based biocomposites
Francesco Carraro, Miriam de J. Velásquez‐Hernández, Efwita Astria, Weibin Liang, Liam Twight, Chiara Parise, Ge Meng, Zhehao Huang, Raffaele Riccò, Xiaodong Zou, Laura Villanova, C. Oliver Kappe, Christian J. Doonan, Paolo Falcaro
Abstract
-1. We examined the influence of the different phases on two properties relevant to drug delivery applications: encapsulation efficiency and release profile. The encapsulation efficiencies of bovine serum albumin and insulin were phase dependent and ranged from 75% to 100%. In addition, release profiles showed that 100% protein release varied between 40 and 300 minutes depending on the phase. This study provides a detailed compositional map for the targeted preparation of ZIF-based biocomposites of specific phases and a tool for the straightforward analysis of the crystalline phases of ZIF based materials (web application named "ZIF phase analysis"). These data will facilitate the progress of ZIF bio-composites in the fields of biomedicine and biotechnology.