The emergence of the C–H functionalization strategy in medicinal chemistry and drug discovery
Ranjan Jana, Hasina Mamataj Begam, Enakshi Dinda
Abstract
The application of representative C–H activation/functionalization reactions for drug synthesis, late-stage modification of pharmacophores, bioconjugation and representative case studies for accelerated drug discovery is highlighted.
Topics & Concepts
Chemical spaceDrug discoveryChemistryADMESurface modificationCombinatorial chemistryNanotechnologyComputational biologyComputer scienceBiologyIn vitroMaterials scienceBiochemistryPhysical chemistryCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSynthesis and Catalytic Reactions