Liver organ-on-chip models for toxicity studies and risk assessment
Taha Messelmani, Lisa Morisseau, Yasuyuki Sakai, Cécile Legallais, Anne Le Goff, Éric Leclerc, Rachid Jellali
Abstract
cellular metabolic responses. In this review, we discuss the development of liver organ-on-chip technology and its use in toxicity studies. First, we introduce the physiology of the liver and summarize the traditional experimental models for toxicity studies. We then present liver OoC technology, including the general concept, materials used, cell sources, and different approaches. We review the prominent liver OoC and multi-OoC integrating the liver for drug and chemical toxicity studies. Finally, we conclude with the future challenges and directions for developing or improving liver OoC models.
Topics & Concepts
Liver toxicityRisk assessmentOrgan-on-a-chipToxicityFocus (optics)Risk analysis (engineering)Computer scienceBusinessMedicineNanotechnologyInternal medicineComputer securityMaterials scienceOpticsMicrofluidicsPhysics3D Printing in Biomedical ResearchNeuroscience and Neural EngineeringInnovative Microfluidic and Catalytic Techniques Innovation