Palladium-catalyzed synthesis of 4-sila-4<i>H</i>-benzo[<i>d</i>][1,3]oxazines by intramolecular Hiyama coupling
Donghyeon Lee, Ryo Shintani
Abstract
A palladium-catalyzed synthesis of 4-sila-4 H -benzo[ d ][1,3]oxazines, silicon-switched analogs of biologically relevant 4 H -benzo[ d ][1,3]oxazines, was developed by the intramolecular Hiyama coupling of 3-amido-2-(arylsilyl)aryl triflates.
Topics & Concepts
OxazinesIntramolecular forcePalladiumChemistryArylCatalysisCoupling (piping)StereochemistryMedicinal chemistryCombinatorial chemistryOrganic chemistryMaterials scienceAlkylMetallurgyCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsSynthesis and Biological Evaluation