Electrochemical C-H Halogenations of Enaminones and Electron-Rich Arenes with Sodium Halide (NaX) as Halogen Source for the Synthesis of 3-Halochromones and Haloarenes
Yan Lin, Jun Jin, Chaoli Wang, Jie‐Ping Wan, Yunyun Liu
Abstract
Without employing an external oxidant, the simple synthesis of 3-halochromones and various halogenated electron-rich arenes has been realized with electrode oxidation by employing the simplest sodium halide (NaX, X = Cl, Br, I) as halogen source. This electrochemical method is advantageous for the simple and mild room temperature operation, environmental friendliness as well as broad substrate scope in both C-H bond donor and halogen source components.
Topics & Concepts
HalideHalogenElectrochemistryChemistrySubstrate (aquarium)Inorganic chemistrySodiumHalogenationElectrodeCombinatorial chemistryOrganic chemistryPhysical chemistryGeologyAlkylOceanographyRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions