Coumarin-Based ACQ-AIE Conversion Photosensitizer for Mitochondrial Imaging and Synergistic Cancer Therapy
Lu Zhang, Fangyuan Chai, Haibo Dong, Yali Bao, Ke Yan, Shuang Min, Yuan Yao, Shun Li, Yi Liu, Yi Liu, Tao Gao, Jianglin Wang, Yujiao Liu, Yujiao Liu
Abstract
Most of the traditional fluorescent molecules have the advantages of high fluorescence quantum yield, good stability, and excellent structural adjustability, but they exhibit the characteristics of fluorescence quenching caused by aggregation, which restricts their application in aqueous solutions or solids. The excellent luminescence properties and photosensitive potential of aggregation-induced emission (AIE) materials in a condensed state have made them widely concerned in the scientific research field, so it is very challenging to regulate the transformation of traditional aggregation-caused quenching (ACQ) fluorophores into AIE fluorophores. In this study, the traditional coumarin fluorophore was used as a matrix. After conjugating the triphenylamine AIE group, the triphenylphosphine cation was linked through the alkyl chain to obtain a molecular probe NCTPP with excellent AIE characteristic, water solubility, mitochondrial green light imaging, chemotherapy and photodynamic therapy capabilities. As far as we know, it was the first time that the photosensitivity of coumarin fluorescent molecules was imparted by the ACQ-AIE conversion method.