Homeorhesis in Waddington's landscape by epigenetic feedback regulation
Yuuki Matsushita, Kunihiko Kaneko
Abstract
The authors introduce a theoretical model that combines gene expression dynamics with epigenetic modification, which changes the feasibility of expression, i.e., the threshold for expression. By taking into account of a slow positive-feedback process from expression to the threshold level, the paper finds several distinct cell types that are given by fixed-point attractors are generated hierarchically.
Topics & Concepts
EpigeneticsBiologyProcess (computing)Expression (computer science)Computer scienceGene expressionDynamics (music)Regulation of gene expressionAttractorEpigenesisNegative feedbackComputational biologyHistoneChromatinGeneNeuroscienceGeneticsDNA methylationGene Regulatory Network AnalysisDevelopmental Biology and Gene RegulationPlanarian Biology and Electrostimulation