Advances in targeting central sensitization and brain plasticity in chronic pain
Amjad H. Bazzari, Firas H. Bazzari
Abstract
Abstract Maladaptation in sensory neural plasticity of nociceptive pathways is associated with various types of chronic pain through central sensitization and remodeling of brain connectivity. Within this context, extensive research has been conducted to evaluate the mechanisms and efficacy of certain non-pharmacological pain treatment modalities. These include neurostimulation, virtual reality, cognitive therapy and rehabilitation. Here, we summarize the involved mechanisms and review novel findings in relation to nociceptive desensitization and modulation of plasticity for the management of intractable chronic pain and prevention of acute-to-chronic pain transition.
Topics & Concepts
NeurostimulationChronic painNeuroplasticityNeuroscienceModalitiesContext (archaeology)MedicineSensitizationMaladaptationNociceptionCentral sensitizationDesensitization (medicine)PsychologyCognitionNeurorehabilitationRehabilitationPhysical medicine and rehabilitationStimulationPsychiatryBiologyReceptorPaleontologySocial scienceSociologyInternal medicinePain Mechanisms and TreatmentsMusculoskeletal pain and rehabilitationPain Management and Treatment