Signaling Pathways and Potential Therapeutic Strategies in Cardiac Fibrosis
Alexandrine Foucault‐Bertaud, Ahmad Joshkon, Xavier Heim, Richard Bachelier, Nathalie Bardin, Aurélie S. Leroyer, Marcel Blot‐Chabaud
Abstract
Cardiac fibrosis constitutes irreversible necrosis of the heart muscle as a consequence of different acute (myocardial infarction) or chronic (diabetes, hypertension, …) diseases but also due to genetic alterations or aging. Currently, there is no curative treatment that is able to prevent or attenuate this phenomenon that leads to progressive cardiac dysfunction and life-threatening outcomes. This review summarizes the different targets identified and the new strategies proposed to fight cardiac fibrosis. Future directions, including the use of exosomes or nanoparticles, will also be discussed.
Topics & Concepts
FibrosisMedicineCardiac fibrosisMicrovesiclesMyocardial infarctionDiabetes mellitusBioinformaticsCardiac dysfunctionCardiac muscleMyocardial fibrosisCardiologyInternal medicineHeart failuremicroRNABiologyEndocrinologyBiochemistryGeneCardiac Fibrosis and RemodelingCardiovascular Effects of ExerciseViral Infections and Immunology Research