Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis
Lucy MacDonald, Aziza Elmesmari, Domenico Somma, Jack Frew, Clara Di Mario, Roopa Madhu, Audrey Paoletti, Theodoros Simakou, Olympia M Hardy, Barbara Tolusso, Denise Campobasso, Simone Perniola, Marco Gessi, Maria Rita Gigante, Luca Petricca, Dario Bruno, Lavinia Agra Coletto, Roberta Benvenuto, John D. Isaacs, Andrew Filby, David McDonald, Jasmine P X Sim, Nigel B. Jamieson, Kevin Wei, Maria Antonietta D’Agostino, Neal L. Millar, Simon Milling, Charles McSharry, Elisa Gremese, Karen Affleck, Kenneth F. Baker, Iain B. McInnes, Thomas D. Otto, Ilya Korsunsky, Stefano Alivernini, Mariola Kurowska‐Stolarska
Abstract
DC2s, which interacted with naive T cells, potentially driving the local expansion of new effector T cells. Remission saw the resolution of these pathogenic niches but lacked recovery of tolerogenic DC2s and exhibited activation of blood precursors of ST-DC3 clusters prior to flare-ups. Targeting pathogenic DC3s or restoring tolerogenic DC2s may help restore immune homeostasis in RA joints.