Parathyroid hormone signaling in mature osteoblasts/osteocytes protects mice from age-related bone loss
Yuhei Uda, Vaibhav Saini, Christopher A. Petty, Majed Alshehri, Chao Shi, Jordan Spatz, Roberto Nunes Campos E. Santos, Carly M. Newell, Tim Y. Huang, Alejandro Kochen, Ji Won Kim, Christodoulos K. Constantinou, Hiroaki Saito, Kathryn D. Held, Eric Hesse, Paola Divieti Pajevic
Abstract
studies demonstrated that PTH protects osteocytes from oxidative stress-induced cell death. In summary, we reported that PPR signaling in osteocytes is important for protecting the skeleton from age-induced bone loss by restraining osteoclast's activity and protecting osteocytes from oxidative stresses.
Topics & Concepts
OsteocyteOsteoblastParathyroid hormoneEndocrinologyInternal medicineSclerostinOsteoclastBone resorptionChemistryBone remodelingAnabolismBone cellOsteopeniaOxidative stressCell biologySignal transductionOsteoporosisWnt signaling pathwayMedicineBiologyReceptorCalciumBone mineralIn vitroBiochemistryBone Metabolism and DiseasesBone health and treatmentsParathyroid Disorders and Treatments