The shared KEGG pathways between icariin-targeted genes and osteoporosis
Tao Yu, Yuan Xiong, Simon Luu, Xiaomeng You, Bing Li, Jiang Xia, Hui Zhu, Youguang Zhao, Haichao Zhou, Guangrong Yu, Yunfeng Yang
Abstract
data show that icariin inhibits apoptosis in human mesenchymal stem cells by suppressing JNK/c-Jun signaling pathway. Together, these findings indicate that icariin exerts its anti-osteoporotic function by inhibiting JNK/c-Jun signaling pathway, and suggest that icariin may be a promising treatment option for osteoporosis.
Topics & Concepts
IcariinSignal transductionKEGGMAPK/ERK pathwayPI3K/AKT/mTOR pathwayCancer researchBiologyCell biologyMedicineBioinformaticsTranscriptomeGeneGeneticsGene expressionPathologyAlternative medicineMedicinal Plant Pharmacodynamics ResearchBone Metabolism and DiseasesCancer-related molecular mechanisms research