Dietary nobiletin regulated cefuroxime- and levofloxacin-associated “gut microbiota-metabolism” imbalance and intestinal barrier dysfunction in mice
Minmin Zhan, Xiaoshuang Yang, Chenxi Zhao, Yanhui Han, Peichun Xie, Zheqi Mo, Jie Xiao, Yong Cao, Hang Xiao, Mingyue Song
Abstract
and regulated the metabolic disorders of short-chain fatty acids (SCFAs) and bile acids (BAs). Notably, NOB supplementation resulted in elevated levels of butyric acid and lithocholic acid (LCA), which contributed to the repair of the intestinal mucosal barrier function and the maintenance of intestinal homeostasis. Collectively, our results propose a healthy dietary strategy for the prevention or mitigation of antibiotic-associated gut dysbiosis by dietary NOB.
Topics & Concepts
Intestinal permeabilityBarrier functionGut floraLachnospiraceaeDysbiosisIntestinal DisorderRoseburiaNobiletinBile acidLithocholic acidLipopolysaccharideMicrobiologyInternal medicineBiologyImmunologyEndocrinologyMedicineLactobacillusBiochemistryDiseaseFirmicutesFlavonoidAntioxidantCell biologyGeneFermentation16S ribosomal RNAGinger and Zingiberaceae researchBarrier Structure and Function StudiesBerberine and alkaloids research