An activatable probe for detecting alcoholic liver injury <i>via</i> multispectral optoacoustic tomography and fluorescence imaging
Junjie Chen, Yichang Fang, Lihe Sun, Fang Zeng, Shuizhu Wu
Abstract
A probe has been developed for imaging alcoholic liver injury through detecting the overexpressed cytochrome P450 reductase in hypoxia in the hepatic region. Upon response to the enzyme, the activated probe displays turn-on fluorescence and near-infrared absorption and generates prominent optoacoustic signals.
Topics & Concepts
Multispectral imageFluorescenceLiver injuryTomographyMedicineChemistryRadiologyPathologyInternal medicineOpticsComputer sciencePhysicsComputer visionEicosanoids and Hypertension PharmacologyAlcohol Consumption and Health EffectsHeme Oxygenase-1 and Carbon Monoxide